Inbox2 does a great job of combining your email, Twitter, Facebook, and others.
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Like its original webapp, the Inbox2 beta for Windows does a great job of combining your email, Twitter, Facebook, and other social messages into one sortable stream.
It also respects your email labels and stars and adds simple task management tools. The benefit to a tool like Inbox2 is that you can take all your communication and process it the way you would email, so Inbox2 has three buttons—Todo, Waiting For, and Someday—that help manage your communiques and seem a lot like, well, the Trusted Trio.Inbox2 is a free download for Windows systems only.
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